Fig. 8.

Inhibition of SFKs attenuated the activation of pancreatic STAT3, NFκB, AP-1, and MAP kinases in acute pancreatitis. Mice (n = 10 in each group) were given 10 hourly injections of caerulein (50 μg/kg i.p.). PP2 was administered to mice at a dose of 1 mg/kg i.p. 1 h before or 1 h after the first caerulein injection. One hour after the last caerulein injection, mice were sacrificed by an intraperitoneal injection of a lethal dose of pentobarbitone. The activation of pancreatic STAT3 (a), NFκB (b), AP-1 (c), and MAP kinases (d-f) was quantified as described under Materials and Methods. Results shown are the means + S.E. ^*, P ≤ 0.05 when caerulein-treated animals were compared with placebo-treated animals. +, P ≤ 0.05 when PP2-treated animals were compared with caerulein-treated animals.