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Pharmacokinetics of PPI-2458. A, AUC, Cmax, Tmax, half-life, and dose-adjusted bioavailability are shown for intravenous, subcutaneous, and oral routes of administration. B, mean serum levels of PPI-2458 (±S.E.M.) are shown after a single dose of 100 mg/kg p.o. in normal LOU rats.
