Fig. 6.

Radiographic damage. Left, a normal limb. Middle, an arthritic control limb on day 28. Periarticular soft tissue swelling (arrows) and severe periosteal reactions/osteolysis/erosions (within the dashed circles) are evident at the tarsus, tarsals, and metatarsophalangeal joints [radiographic score is 3 (maximum)]. Right, a hind limb, day 28 (18 days after arthritis onset on day 10), treated with PPI-2458 (30 mg/kg s.c. q.o.d). No soft tissue swelling or bone destruction is evident, and it seems similar to the normal limb (radiographic score is 0).