Table 3.
Down-regulated genes Functional classes of genes shown are ordered by the S score of the most highly regulated examples in the class with S score ≤ -2.6.
| Function | Symbol | Name | S Score |
|---|---|---|---|
| Cell cycle, DNA replication and Mitosis | ID1 | Inhibitor Of DNA Binding 1 | -4.416 |
| ID3 | Inhibitor Of DNA Binding 3 | -4.304 | |
| ID2 | Inhibitor Of DNA Binding 2 | -4.054 | |
| LHX3 | LIM Homeobox 3 | -3.181 | |
| KLF1 | Kruppel-Like Factor 1 | -2.97 | |
| FOXF2 | Forkhead Box F2 | -2.684 | |
| SFN | Stratifin | -4.086 | |
| FGFBP1 | Fibroblast Growth Factor Binding Protein 1 | -3.922 | |
| SKP2 | S-Phase Kinase-Associated Protein 2 (P45) | -3.035 | |
| RPA3 | Replication Protein A3 | -2.975 | |
| RFC4 | Replication Factor C 4 | -2.845 | |
| SPBC25 | Spindle Pole Body Component 25 Homolog | -2.688 | |
| Structural | REG1A | Regenerating Islet-Derived 1 Alpha | -4.213 |
| CX36 | Connexin-36 | -3.79 | |
| COL4A5 | Collagen, Type IV, Alpha 5 | -3.69 | |
| ODF1 | Outer Dense Fiber Of Sperm Tails 1 | -3.511 | |
| CD248 | CD248 Molecule, Endosialin | -2.965 | |
| Membrane transport | SLC2A1 | Solute Carrier Family 2, Member 1 | -3.912 |
| CRIP1 | Cysteine-Rich Protein 1 (Intestinal) | -3.079 | |
| SCNN1A | Sodium Channel, Nonvoltage-Gated 1 Alpha | -2.918 | |
| HFE | Hemochromatosis Gene | -2.723 | |
| Transcription, protein synthesis and export | CHMP6 | Chromatin Modifying Protein 6 | -3.599 |
| RANBP1 | RAN Binding Protein 1 | -3.48 | |
| EHBP1 | EH Domain Binding Protein 1 | -3.106 | |
| RRM2 | Ribonucleotide Reductase M2 Polypeptide | -2.957 | |
| CTDSPL | Small Carboxy-Terminal Domain Phosphatase | -2.838 | |
| DARS2 | Aspartyl-Trna Synthetase 2 (Mitochondrial) | -2.795 | |
| POLR3K | Polymerase (RNA) Subunit K | -2.701 | |
| Nucleotide synthesis | UNG | Uracil-DNA Glycosylase | -3.553 |
| GLRX | Glutaredoxin | -3.325 | |
| DUT | dUTP Pyrophosphatase | -2.967 | |
| TYMS | Thymidylate Synthetase | -2.687 | |
| Energy metabolism | ATAD4 | ATPase Family, AAA Domain Containing 4 | -3.185 |
| COX7B | Cytochrome C Oxidase Subunit 7B | -2.893 | |
| Cytoskeleton/cytokinesis | M-RIP | Myosin Phosphatase-Rho Interacting Protein | -2.954 |
| MALL | Mal, T-Cell Differentiation Protein-Like | -2.918 | |
| ARHGAP29 | Rho Gtpase Activating Protein 29 | -2.909 | |
| ROCK2 | Rho-Associated, Coiled-Coil Containing Protein Kinase 2 | -2.701 | |
| Cytokine | TGFB2 | Transforming Growth Factor, Beta 2 | -2.909 |
| C1QTNF3 | C1q And TNF Related Protein 3 | 2.701 | |
| Protease | SPINK1 | Serine Peptidase Inhibitor, Kazal Type 1 | -2.889 |
| Cell adhesion | LGALS4 | Galectin 4 | -2.869 |
| Redox | TXNIP | Thioredoxin Interacting Protein | -2.843 |
| Cell signalling | HS1BP3 | HS1-Binding Protein 3 | -2.755 |
| Anti-inflammatory | ANXA1 | Annexin A1 (Lipocortin 1) | -2.703 |
| Matrix | LAMB1 | Laminin, Beta 1 | -2.702 |