Table 1.

Functional analysis of the 231 significantly up-regulated transcripts upon MHV-68 infection. (A) Analysis of overrepresentation of gene categories for induced transcripts. Gene categories were assigned to the list of 231 up-regulated genes with the program EASE. The probability of seeing the number of ‘List Hits' in the ‘List Total’, given the frequency of ‘Population Hits' in the ‘Population Total’, is calculated by the Fisher exact probability and the P-values are shown in the last column. (B) Selected genes were manually assigned to functional biological categories. For each of the three cell lines, the average fold-change (FC) is shown.

A
System	Gene category	List hits	List total	Population hits	Population total	Probability
GO Biological process	Defense response	45	168	629	7516	7*10−13
GO Biological process	Innate immune response	17	168	146	7516	2*10−08
GO Biological process	Chemotaxis	13	168	95	7516	2*10−07
SwissProt keywordinte	Interferon induction	7	130	27	5351	3*10−06
GO Molecular function	Chemokine receptor binding activity	7	170	30	7550	3*10−06
GO Molecular function	Cytokine activity	15	170	177	7550	1*10−05
SwissProt keywordinte	MHC I	4	130	10	5351	6*10−05
GO Molecular function	Antiviral response protein activity	5	170	24	7550	1*10−04