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aReagents and conditions: (i) (PhO)2PON3, Et3N, PhCH2OH, PhH, 3 h; (ii) NaH, MeI, rt, 2 h; (iii) Pd/C, H2, EtOAc, 30 psi, 1 h; (iv) diethyl malonate, 100–110 °C, 3 h; (v) (a) NaOH, 60 °C, 2 h, (b) HCl; (vi) PPA, 95–100 °C 3 h; (vii) TMSCH2N2, MeOH-Et2O, rt, 24 h
