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. 2009 May;15(5):781–793. doi: 10.1261/rna.1448009

FIGURE 1.

FIGURE 1.

Domain structure of selected GW-182-like proteins. (A) Schematic representation of human (Hs) TNRC6A, TNRC6B, and TNRC6C proteins, the Drosophila (Dm) GW182 (dGW182), C. elegans (Ce) AIN-1 and AIN-2, and a candidate GW182 ortholog of Brugia malayi (Bm). Positions of GW-rich, Q-rich, UBA (ubiquitin-associated), DUF (domain of unknown function), and RRM domains are indicated. The percentage of amino acid identity between highlighted regions of Drosophila, C. elegans, and B. malayi proteins is indicated. (B) Amino acid alignments of DUF domains of selected GW proteins. Positions of amino acids that have been mutated to alanines, either singly (T1410) or in the combination of two (EF1388/1389 and WK1395/1396), are indicated. (Blue) Amino acids identical in more than 50% of proteins; (green) conservative substitutions by related amino acids.