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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Cell Signal. 2009 Jan 8;21(5):727–736. doi: 10.1016/j.cellsig.2009.01.011

Fig. 3. Geldanamycin abrogates the PTP inhibitor-induced increase in clonogenic survival following Cr(VI) treatment.

Fig. 3

(A) HLFs at 24 hr post-seeding were treated with either 1 μM geldanamycin (GA) or DMSO for 24 hr and total lysates were collected and analyzed for expression of indicated proteins by immunoblotting. Numbers under the blot show individual protein expression normalized by α-tubulin level. (B) HLFs at 24 hr post-seeding were pretreated with either 1 μM GA or DMSO for 30 min and treated with 1 and 2 μM Cr(VI) with or without 10 μM SOV for 24 hr, then seeded for colony formation. Data are expressed as percent clonogenic survival of Cr 0μM control, and are the average ± SE from 4 experiments performed in triplicate. *: statistically significant difference between the samples with and without SOV at p<0.05. #: statistically significant difference for two compared groups indicated by dotted line at p<0.05.