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. Author manuscript; available in PMC: 2009 Apr 24.
Published in final edited form as: Nat Chem Biol. 2008 May 30;4(7):418–424. doi: 10.1038/nchembio.94

Figure 5.

Figure 5

Inhibition of ATP (18) production in A549 cells in response to treatment with neopeltolide 2 and leucascandrolide analog 3, in the presence or absence of 2-DG (24). Whole-cell ATP content in the presence and absence of 2-DG was 25×10−6 nmol/cell and 37 ×10−6 nmol/cell, respectively. All values are presented as % of vehicle treated sample. Each value is mean ± SEM of duplicate values from a representative experiment. (a) ATP depletion upon treatment with a combination of neopeltolide 2 and 2-DG (10 mM). (b) ATP depletion upon treatment with a combination of leucascandrolide analog 3 and 2-DG (10 mM). (c) Treatment of cells with a combination of taxol (25) and 2-DG does not effect ATP levels significantly within 30 min of incubation. (d) Constant level of ATP after treatment of cells with neopeltolide 2 in the absence of 2-DG. (e) Constant level of ATP after treatment of cells with analog 3 in the absence of 2-DG.