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. 2009 Apr 24;106(19):7985–7990. doi: 10.1073/pnas.0811834106

Fig. 1.

Fig. 1.

Deletion of FP reduces BP and decreases renin-angiotensin-aldosterone concentration. Systolic BP (SBP) measurements in (A) FP−/− mice on a normal chow diet and after salt depletion by tail cuff and Ldlr−/−/FP−/− on HFD for either (B) 12 weeks by tail cuff or (C) 24 weeks by radiotelemetry. Values represent mean ± SEMs analyzed by unpaired Student t test. *, P < 0.05 versus WT controls (n = 11–16), *, P < 0.05, ***, P < 0.0001 versus Ldlr−/− controls (n = 16–18). (D) Plasma renin concentration (PRC), (E) plasma angiotensinogen I concentration, and (F) plasma aldosterone concentration (PAC) in FP−/− mice under normal and salt-depleted conditions. For salt depletion, mice were subjected to a low-salt diet (0.12% NaCl) and injected with furosemide (25 mg/kg i.p.) every day. Values represent mean ± SEMs analyzed by unpaired Student t test. *, P < 0.05 versus WT control mice (n = 6–9).