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. 2009 Mar 14;5:12. doi: 10.1186/1744-8069-5-12

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Copyright © 2009 Kawano et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of thiol-modifying agents on NO-induced K_ATPchannel activation. (A) Representative current traces in inside-out patches at -60 mV holding potential in the presence of 1 mM [ATP]i in large SS neurons. SNAP (100 μM) and DTT (5 mM), a thiol-reducing agent, were added to bath solution as indicated by the horizontal solid bars. Arrows indicate closed channel state. The changes of NPo values are summarized in (B). Values are shown as mean ± SD (n = 7 in each group). (C) Representative current traces in inside-out patches at -60 mV holding potential in the presence of 1 mM [ATP]i in large SS neurons. NEM (5 mM), a thiol alkylating agent, and SNAP (100 μM) were added to bath solution as indicated by the horizontal solid bars. Arrows indicate closed channel state. The changes of NPo values are summarized in (D). Values are shown as mean ± SD (n = 6 in each group).