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A, His391 in human PKM2 is surrounded by hydrophobic residues such as Leu392, Pro446, Tyr390, and Phe395, which make a local hydrophobic cluster. B, Lys422 (blue) with its protruding side chain is found to interact with Ala419 (turquoise) to align the position of Glu418 (orange) of the same monomer to make a stable H-bond with Arg399 (red) of the neighboring monomer.
