FIGURE 1.

Activation of putative and established LPA receptors by LPA and other lipid molecules. Indicated human receptors (A, LPA2; B, GPR92; C, GPR23) were transiently transfected into the HEK293-BAEA parental cell line. 16-24 h later, test compounds (cpd) were added to the cells. 1 h later, the reaction was stopped by the addition of flash detection reagent, and β-galactosidase activity was measured. Relative luminescence unit (RLU) is plotted on the y axis, and the data are expressed as mean ± S.E.