FIGURE 8.

A model for LFA-1-induced STAT3 activation and regulation of MT dynamics. The figure illustrates STAT3 activation by tyrosine phosphorylation, its nuclear translocation, and its predicted interaction with stathmin. Stathmin-bound tubulin heterodimers are unable to polymerize. Activated STAT3 binding to stathmin inhibits its tubulin depolymerization activity, making tubulin available for polymerization in actively migrating T-cells. Dashed lines with arrows indicate that the interactions either are putative or involve multiple steps. P in the solid star, Tyr⁷⁰⁵ phosphorylation.