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A model of regulation of the inhibitory activity of tomosyn upon the tail domain bindings. In state I, tomosyn exposes the VLD upon binding of the tail domain to the N-terminal WD40 repeats, leading to efficient tomosyn complex formation. Eventually, tomosyn potently inhibits SNARE complex formation. In state II, VLD is masked by the tail domain, leading to less formation of the tomosyn complex. Eventually, tomosyn does not inhibit the SNARE complex formation.
