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. Author manuscript; available in PMC: 2009 Oct 15.
Published in final edited form as: J Immunol. 2008 Oct 15;181(8):5278–5288. doi: 10.4049/jimmunol.181.8.5278

FIGURE 4.

FIGURE 4

Increased disease severity in B7− B7-2 Fc Tg mice. A, Histological scores of colitis in B7+ (left, circles) and B7− (right, squares) B7-2 Fc Tg+ mice (filled) compared with Tg− littermates (open). (*, p < 0.05 between B7+ and B7− B7-2 Fc Tg+). B, Number of CD11b+ cells in the spleen (left) and CD19+ cells in the MLN (right) of diseased B7+ B7-2 Fc Tg+ mice (●), B7− B7-2 Fc Tg+ mice (■) and B7− B7-2 Fc Tg− littermates (□). C, Serum IgG1, IgG2a and IgM concentrations from the B7-2 Fc Tg+ (filled) and B7-2 Fc Tg− (open) littermates that are B7+ (circles) and B7− (squares).*, Significant (p < 0.05) differences.