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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Matrix Biol. 2009 Jan 20;28(2):65–73. doi: 10.1016/j.matbio.2009.01.001

Figure 6. MMP-9 is critical for keratinocyte wound migration in vitro.

Figure 6

A. Human keratinocyte monolayer cultures were wounded and allowed to heal in the presence of a function-blocking anti-MMP-9 antibody. Representative images from cultures treated with isotype control antibody (top row) or anti-MMP-9 antibody (bottom row) at 24 and 48 hr show the retarded healing in the latter. B. Representative images of mouse keratinocytes from WT (top row) and MMP-9 KO (bottom row) mice subjected to the same scratch assay at 0, 24, and 48 hr are shown. C. Measurement of migration, expressed as percent closure, indicated a defect in MMP-9 KO keratinocytes. Triplicate wells were used and the experiment was repeated three times. n = 6; * p value ≤ 0.01.