Table 1.
Genetic alterations observed in gallbladder carcinomas from Japan and Hungary
| Case No | Age (yr) | Sex |
Histology1 |
p53 mutation |
K-ras mutation |
Microsatellite instability | ||
| Type | Grade | Exon/codon | Base change | Base change | ||||
| Japanese cases | ||||||||
| 1 | 71 | F | PAP | G1 | None | - | None | BAT25, BAT26 |
| 2 | 74 | F | AD | G1 | Exon 5/codon 132 | AAG to GAG | None | BAT25, D2S123 |
| 3 | 62 | F | PAP | G1 | None | - | None | BAT25 |
| 4 | 76 | F | AD | G1 | Exon 6/codon 193 | CAT to AAT | None | BAT25, BAT26 |
| 5 | 78 | F | AD | G2 | Exon 5/codon 140 | ACC to ATC | None | ND |
| Exon 5/codon 166 | TCA to ACA | |||||||
| 6 | 70 | F | AD | G1 | Exon 8/codon 276 | GCC to CCC | None | None |
| 7 | 71 | F | AD | G1 | None | - | None | BAT26, D2S123 |
| 8 | 79 | F | AD | G1 | None | - | None | None |
| 9 | 66 | F | PAP | G1 | None | - | None | None |
| 10 | 60 | F | PAP | G1 | None | - | None | None |
| 11 | 80 | M | PAP | G1 | None | - | None | BAT26 |
| 12 | 63 | M | PAP | G1 | Exon 8/codon 294 | GAG to GAA | None | BAT25, BAT26 |
| 13 | 49 | F | PAP | G1 | None | - | None | D2S123 |
| 14 | 71 | M | AD | G2 | Exon 8/codon 280 | AGA to AAA | None | BAT25, D2S123 |
| 15 | 70 | M | AD | G1 | Exon 7/codon 238 | TGT to CGT | None | ND |
| 16 | 53 | M | AD | G1 | None | - | None | None |
| 17 | 79 | F | AD | G3 | Exon 8/codon 271 | GAG to AAG | None | None |
| 18 | 62 | M | AD | G3 | Exon 6/codon 205 | TAT to TGT | None | None |
| 19 | 61 | M | AD | G1 | None | - | None | D17S250, D2S123 |
| 20 | 69 | M | AD | G2 | Exon 7/codon 231 | ACC to ATC | None | BAT25, D17S250 |
| 21 | 58 | F | AD | G2 | Exon 5/codon 160 | ATG to GTG | None | ND |
| Exon 6/codon 220 | TAT to AAT | |||||||
| 22 | 76 | F | AD | G3 | None | - | None | None |
| Hungarian cases | ||||||||
| 23 | 71 | M | AD | G2 | Exon 7/codon 249 | AGG to ACG | None | BAT26 |
| 24 | 69 | F | AD | G3 | Exon 6/codon 213 | CAG to CGG | None | None |
| 25 | 69 | F | AD | G2 | None | - | None | None |
| 26 | 76 | F | AD | G2 | None | - | None | None |
| 27 | 61 | F | AD | G3 | None | - | None | None |
| 28 | 58 | F | AD | G3 | None | - | None | BAT25 |
| 29 | 69 | F | AD | G3 | None | - | None | None |
| 30 | 75 | F | PAP | G1 | None | - | None | None |
| 31 | 66 | F | AD | G3 | None | - | None | None |
| 32 | 65 | F | AD | G1 | Exon 6/codon 219 | CCC to TCC | None | ND |
| 33 | 61 | F | AD | G3 | ND | - | None | ND |
| 34 | Unknown | F | PAP | G1 | Exon 5/codon 138 | GCC to GCT | None | BAT25, D17S250 |
| Exon 5/codon 167 | CAG to CAA | |||||||
| Exon 5/codon 170 | ACG to ACA | |||||||
| 35 | Unknown | F | PAP | G1 | Exon 5/codon 158 | CGC to TGC | GGT to AGT | ND |
| Exon 6/codon 223 | CCT to TCT | |||||||
| 36 | Unknown | F | AD | G3 | Exon 6/codon 210 | AAC to AAT | None | ND |
| Exon 7/codon 228 | GAC to AAC | |||||||
| 37 | Unknown | F | AD | G2 | ND | - | None | ND |
| 38 | 53 | F | AD | G3 | None | - | None | None |
| 39 | 72 | Unknown | AD | G1 | None | - | None | None |
| 40 | 69 | M | AD | G1 | None | - | None | BAT26 |
| 41 | 57 | F | AD | G1 | None | - | None | None |
| 42 | 74 | F | AD | G1 | None | - | None | BAT25 |
1
According to the tumor-node-metastasis (TNM) staging system[18]. PAP: Papillary carcinoma; AD: Adenocarcinoma; ND: Not detected; G1: Well differentiated; G2: Moderately differentiated; G3: Poorly differentiated.