Table 5.

Examples of 4 × 4 IDI substitution tables

IDI substitution tables for AU cWW (left), AG cWW (middle) and GU cWW (right) base pairs. These tables are specific to each base combination in each base pair family. Each table shows the IDI values between the base pair indicated in the upper left cell and all other base combinations in that family and is color-coded to show which base pair substitutions are isosteric (red), near isosteric (yellow) or non-isosteric (blue). Left panel: CG, GC and UA are isosteric to AU. Middle panel: GA is isosteric to AG. Right panel: AC is isosteric to GU. Tables for each combination and each base family are available in Supplementary Data S7.