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IM for the tWH family determined from IDI values (Supplementary Data S6)
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The tWH base pairs UA and CC belong to isosteric group I4.1, CA, CG, UU and AG belong to I4.2, AA, AG and GU, I4.3, while UG and GG each have their own isosteric groups, I4.4 and I4.5. Note that AG belongs to two groups, I4.2 and I4.3. The AU, CU, GA, GC and UC base combinations do not occur in this geometric family and their cells are shaded gray in the IM.
