Table 3.
Spontaneous rifampicin resistant mutations in E. coli strains with different DNA glycosylase activities
| Relevant genotype | Rifampicin resistant mutants/108 cells |
|---|---|
| wild-type | 21 ± 10 |
| mutM | 122 ± 23 |
| mutY | 255 ± 25 |
| ksgA | 72 ± 18 |
| mutM ksgA | 264 ± 30 |
| mutY ksgA | 227 ± 27 |
| mutM mutY | 985 ± 35 |
| mutM mutY ksgA | 2 691 ± 136 |
| nth nei | 122 ± 40 |
| nth nei ksgA | 402 ± 24 |
Rifampicin was added at 150 μg/ml on LB-agar plates. The values represent the mean ± SD (n = 4). The P < 0.05, indicating significant difference at the 95% confidence level.