Figure 5.

Pixelwise correlations between DTI parameters and EAE scores. Four adjacent slices of lumbar spinal cord segments L1 and L2 are shown. Axial diffusivity and RA were significantly correlated with EAE score in nearly the entire ventrolateral white matter and the most dorsal portion of the dorsal white matter. Radial diffusivity was significantly correlated with EAE score in only a few regions along the periphery of the ventrolateral white matter. Correlation (Spearman's r) maps were thresholded at p < 0.05 and corrected for multiple comparisons, and significant voxels were overlaid on the average DTI parameter maps from all mice.