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Mean quantitative histological maps grouped by EAE score. SMI31 staining (left) reveals a loss of intact axons that scales with the severity of EAE (from top to bottom). MBP staining for intact myelin is decreased in the EAE spinal cord white matter, but no consistent relationship with EAE score is evident. DAPI staining is indicative of cellularity and is particularly increased in certain regions in mice with clinical scores of 4 (bottom).
