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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Biomaterials. 2009 Jan 29;30(11):1989–2005. doi: 10.1016/j.biomaterials.2008.11.025

Figure 7.

Figure 7

Outline of applications of different immune evasive tactics from virology and bacteriology to biomaterials. a: Outline of inflammation when immune system is allowed to function unfettered. b: Possible viral design. Virally derived proteins like MT-7 can be released from a coating around the biomaterial to occupy chemokine binding domains and limit formation of a chemokine gradient. c: Possible bacterial design: By coating the material in an artificial derivative of a capsular polysaccharide, deposition of blood borne proteins will decrease, thereby limiting opsonization and inflammatory response. A similar approach would be coating the material in bacterially derived proteins that will inhibit complement deposition. d: A possible combination of viral and bacterial mechanisms. By coating the material in an artificial derivative of a capsular polysaccharide, the surface will become anti-biofouling. Additionally, the presence of viroreceptors will bind cytokines with high specificity, inhibiting the cytokine’s ability to bind to cellular receptors.