Table 1.
Clinical characteristics
| Case No. |
Sex/ Age |
Presentation | Clinical Evidence of Thyroiditis |
Referral Diagnosis |
Ann-Arbor Stage (Other Sites) |
Initial Treatment |
Subsequent Course & Outcome |
|---|---|---|---|---|---|---|---|
| 1 | F 66 | Mass in thyroid gland | Yes | MALT L | 1E | Surgery (TT), RT, AnChT |
CR, ANL (3y) |
| 2 | M 69 | Transient thyrotoxicosis, palpable “cold” nodule |
No | MALT L vs FL | 1E | Surgery (HT), RT |
CR, ANL (18 mo) |
| 3 | F 61 | Mass in thyroid gland | Yes | MALT L | 1E | Surgery (CT)1 | CR, ANL (44 mo) |
| 4 | F 49 | Mass in thyroid gland | No | MALT L | Not staged | Surgery (ST) | CR, ANL (41 mo) |
| 5 | F 47 | Mass in thyroid gland | No | FL & DLBCL | 1E | Surgery (HT), RT, AnChT |
CR, ANL (14 mo) |
| 6 | M 56 | N/A | Yes | MALT L | N/A | N/A | N/A |
| 7 | F 26 | Hypothyroidism | Yes | None given | 1E | Surgery (TT), RT |
CR, ANL (24 mo) |
| 8 | F 47 | Mass in thyroid gland | No | MALT L | 1E | Surgery (HT), AnChT |
CR, ANL (15 mo) |
| 9 | F 62 | Longstanding multinodular goitre |
No | MALT L vs FL | 1E | Surgery (TT), RT, ChT |
CR, ANL (10 y) |
| 10 | F 74 | N/A | N/A | MALT L & DLBCL |
2E (Cervical LN) |
N/A | N/A |
| 11 | F 50 | Multinodular goitre | N/A | Reactive vs FL vs MALT L |
N/A | N/A | N/A |
| 12 | F 39 | N/A | N/A | FL | 2E (Cervical LN) |
N/A | N/A |
| 13 | F ?age | N/A | No | FL vs MALT L | 2E (Cervical LN) |
N/A | N/A |
| 14 | F 56 | Mass in thyroid gland | No | FL | 2E (Cervical LN) |
Surgery (HT), RT, AnChT |
CR Multiple relapses with disseminated FL and DLBCL (1-8y) Several further AnChT & PBSCT DOL (8y) |
| 15 | F 61 | N/A | Yes | MALT L | 1E | Surgery (TT), RT |
CR, ANL (6 y) |
| 16 | F ?age | N/A | N/A | DLBC L | 2E (Cervical LN) |
Surgery, RT, AnChT |
CR, ANL (17y) |
| 17 | M 51 | N/A | No | FL | 3E (Multiple LNs) |
Observation | FL in sigmoid colon (1y) No treatment, AWL (4y) |
| 18 | F 47 | N/A | No | FL | 3E (Multiple LNs) |
Surgery, RT, AnChT |
PR Relapsed with nodal FL (4y) Further ChT Progression to gastric & nodal DLBCL (10y) Further ChT, DOL (11 y) |
| 19 | F 49 | Multinodular goitre | No | MALT L | 3E (Abdominal LNs) |
Surgery (ST), RT, AnChT |
PR Progressive disseminated FL and DLBCL (1-3y) Several further ChT & Rituximab DOL (4y) |
| 20 | M 69 | Mass in neck, mesenteric lymphadenopathy |
N/A | MALT L & DLBCL | ≥3E (Mesenteric LNs) |
N/A | N/A |
| 21 | F 42 | N/A | No | FL & DLBCL | 4E (Multiple LNs, bone marrow) |
Surgery, AnChT |
PR Relapsed with cervical DLBCL (3y) Further ChT, Rituximab & allo-BMT ANL (4y) |
| 22 | F 37 | Mass in thyroid gland | Yes | MALT L | 4E (Cervical LN; bone marrow) |
Surgery (TT), RT |
PR Progressive disseminated FL & DLBCL Several further AnChT & Rituximab DOL (11y) |
N/A, not available; MALT L, extranodal marginal zone lymphoma of MALT type (MALT lymphoma); FL, follicular lymphoma; DLBCL, diffuse large B cell lymphoma; LN, lymph node; HT, hemithyroidectomy; TT, total thyroidectomy; CT, completion thyroidectomy; ST, subtotal thyroidectomy; RT, radiotherapy; ChT, non-anthracycline-containing chemotherapy; AnChT, anthracycline-containing chemotherapy; PBSCT, peripheral blood stem cell transplant; CR, complete response; ANL, alive no lymphoma; DOL, died of lymphoma; AWL, alive with lymphoma.
1
Completion thyroidectomy after hemithyroidectomy for Hashimoto thyroiditis 9 years previously.