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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Eur J Pain. 2008 Jun 12;13(3):253–262. doi: 10.1016/j.ejpain.2008.04.014

Figure 3.

Figure 3

Vascular and nociceptive changes after tibia fracture with and without prolonged PTX treatment. Treatment with PTX appeared to diminish hindpaw edema (but did not reach significance on ANOVA test, panel A), decreased warmth (panel B) and reversed the hindpaw mechanical allodynia (panel C) that developed after fracture. It also partially restored normally distributed hindlimb weight bearing (panel D). Measurements presented in panels A, B, and C represent the difference between the fracture side and the contralateral paw. The data presented in panel D represent the percentage weight bearing on the fracture hindlimb versus normal (100%) weight bearing on that limb if the animal’s weight were evenly distributed. A value of 100%, therefore, represents equally distributed weight (n = 8 per cohort). *P < 0.05, **P < 0.01 and ***P < 0.001 fracture vs. control groups, and #P < 0.05 and ###P<0.001 fracture/PTX treated vs fracture/plain water groups.

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