Table 1.
All Methotrexate Single Nucleotide Polymorphisms Studied in Rheumatoid Arthritis Efficacy and Toxicity
| Polymorphism | Number of articles | Efficacy, Toxicity, or Both |
|---|---|---|
| MTHFR C677T | van Ede, 200123 Urano 200222 Kumagi 200320 Berkun 200418 Wessels 200624 Kim 200619 *Dervieux 200626 Aggarwal 200617 Taniguchi 200721 *Kurzawski 200729 |
Toxicity Both Both Toxicity Both Toxicity Both Both Both Efficacy |
| MTHFR A1298C | Kumagi 200320 Berkun 200418 Wessels 200624 *Dervieux 200626 Taniguchi 200721 *Kurzawski 200729 |
Both Toxicity Both Both Both Efficacy |
| TYMS 3’UTR | Kumagi 200320 Takatori 200631 |
Both Both |
| TSER*2*3 |
*Dervieux 200427 *Dervieux 200626 |
Efficacy Both |
| RFC1 G80A |
*Dervieux 200427 *Wessels 200624 *Dervieux 200626 Takatori 200631 Drozdzik 200628 |
Efficacy Both Both Both Efficacy |
| ATIC C347G |
*Dervieux 200427 *Wessels 200624 *Dervieux 200626 Takatori 200631 |
Efficacy Both Both Both |
| ITPA C94A | Wessels 200624 | Both |
| MTXPGs | *Dervieux 200427 | Efficacy |
| DHFR –G473A | Wessels 200624 | Both |
| DHFR G35289A | Wessels 200624 | Both |
| HLA-G 14b | Rizzo 200630 | Efficacy |
| HLA DRB1 | Ali 200625 | Efficacy |
| HLADQB1 | Ali 200625 | Efficacy |
| MDR1 C3435T | Drodzik 200628 | Efficacy |
| AMPD1 C34T | Wessels 200624 | Both |
| MTR A2756G | Wessels 200624 | Both |
| MS A2756G | *Dervieux 200626 | Both |
| MTRR A66G | Wessels 200624 *Dervieux 200626 |
Both Both |
| GGH C401T | *Dervieux 200626 | Both |
| GGH C452T | van der Stratten 200732 | Both |
| GGH T16C | van der Stratten 200732 | Both |
| SHMT1 C1420T | Dervieux 200626 | Both |
| ABCB1 C3435T | Takatori 200631 | Both |
| FPGS A1994G | van der Stratten 200732 | Both |
| FPGS G114A | van der Stratten 200732 | Both |
MTHFR Methylenetetrahydrofolate Reductase, TYMS thymidylate synthase, TSER thymidilate synthase enhancer region, RFC1 Reduced Folate Carrier1, ATIC 5 aminoimidazole-4-carboxamide ribonucleotide transformylase, ITPA inosine triphosphate phosphatase, MTXPGs Methotrexate Polyglutamtes, DHFR dihydrofolate reductase, HLA Human Leukocyate Antigen, MDR1 multidrug resistance 1, AMPD1 adenosine monophosphate deaminase 1, MTR methionine synthase, MTRR methionine synthase reductase, GGH gamma glutamyl hydrolase, MS methionine synthase, SHMT1 serine hydroxymethyl transferase 1, ABCB1 ATP binding cassette transporter B1, FPGS folylpoly-gamma-glutamase synthetase
Insufficient data in article to permit inclusion in meta-analysis