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. Author manuscript; available in PMC: 2009 Apr 27.
Published in final edited form as: Mol Cell Biochem. 2008 Jul 5;318(1-2):175–181. doi: 10.1007/s11010-008-9867-5

Table 2.

Effects of hypobaric hypoxia on cardiac contractile function

Normoxic Hypoxic
RV cardiac parameters
 Coronary flow (ml/min) 10.6 ± 0.4 14.3 ± 1.1**
 Heart rate (beats min−1) 260 ± 11.5 253 ± 26
 Systolic pressure (mmHg) 55 ± 2.1 66.3 ± 5.1*
 Developed pressure (mmHg) 43 ± 2.1 54.3 ± 5.1*
 Rate pressure product (beats min−1 mmHg) 11,257 ± 842 13,993 ± 2,214
LV cardiac parameters
 Coronary flow (ml/min) 12.4 ± 0.97 17.1 ± 1.5*
 Heart rate (beats min−1) 266 ± 12.9 306 ± 21.7
 Systolic pressure (mmHg) 95.3 ± 5.6 81.7 ± 8.1*
 Developed pressure (mmHg) 83.3 ± 5.6 69.7 ± 8.1*
 Rate pressure product (beats min−1 mmHg) 22,395 ± 2,082 20,700 ± 1,517

Rats were exposed to hypobaric hypoxia (11% O2) for 4 weeks and compared with age-matched normoxic groups. Data are presented as means ± SEM.

*

P < 0.05 and

**

P < 0.01 vs. normoxic controls (n = 6 animals per group)