Table 3.

Two-parameter discrimination analysis with ideal system performance and inclusion of biological variability from binary classification tasks.

Normal vs prodromal, system	Simultaneous	Sequential	Significance p
PET	—	1.000	—
SPECT, ΔE=9.2%, two heads	0.971±0.005	0.920±0.008	<0.001
SPECT, ΔE=6.2%, two heads	0.982±0.003	0.932±0.008	<0.001
SPECT, ΔE=9.2%, three heads	0.990±0.002	0.959±0.006	<0.001
SPECT, ΔE=6.2%, three heads	0.995±0.002	0.963±0.005	<0.001
Normal vs prodromal, BV
PET	—	0.924±0.009
SPECT, ΔE=9.2%, two heads	0.863±0.011	0.831±0.013	0.019
SPECT, ΔE=6.2%, two heads	0.881±0.011	0.845±0.012	0.006
SPECT, ΔE=9.2%, three heads	0.878±0.011	0.851±0.012	0.030
SPECT, ΔE=6.2%, three heads	0.885±0.010	0.859±0.012	0.010
Prodromal vs early, system	Simultaneous	Sequential	Significance p
PET	—	1.000	—
SPECT, ΔE=9.2%, two heads	0.969±0.005	0.919±0.008	<0.001
SPECT, ΔE=6.2%, two heads	0.978±0.004	0.928±0.008	<0.001
SPECT, ΔE=9.2%, three heads	0.987±0.003	0.956±0.006	<0.001
SPECT, ΔE=6.2%, three heads	0.992±0.002	0.959±0.006	<0.001
Prodromal vs early, BV
PET	—	0.962±0.006
SPECT, ΔE=9.2%, two heads	0.864±0.011	0.833±0.013	0.019
SPECT, ΔE=6.2%, two heads	0.864±0.012	0.834±0.013	0.028
SPECT, ΔE=9.2%, three heads	0.883±0.011	0.861±0.011	0.054
SPECT, ΔE=6.2%, three heads	0.887±0.010	0.864±0.011	0.034