Table.

Effect of Treatment on Baseline Characteristics

Parameter	Placebo	17β-Estradiol	P Value
Systolic blood pressure, mm Hg	112.0±3.1	110.3±2.7	0.584
Diastolic blood pressure, mm Hg	69.4±1.6	68.3±2.4	0.747
Mean arterial pressure, mm Hg	83.6±1.7	82.3±2.3	0.650
Heart rate, bpm	67.9±2.4	68.9±2.7	0.492
Baseline FBF, mL/min per 100 mL	3.6±0.6	4.0±0.7	0.174
Baseline FVR, mlL/min/mm Hg per 100 mL	30.3±4.9	28.4±3.3	0.108
Baseline venous PAI-1 antigen, ng/mL	10.4±2.5	4.4±1.4	0.001
Baseline venous t-PA antigen, ng/mL	7.5±1.3	5.5±0.6	0.022
Baseline venous t-PA activity, IU/mL	0.6±0.1	0.7±0.1	0.415

FBF indicates forearm blood flow; FVR, forearm vascular resistance; PAI-1, plasminogen activator inhibitor-1; t-PA, tissue-type plasminogen activator.