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. Author manuscript; available in PMC: 2010 Apr 7.
Published in final edited form as: J Theor Biol. 2008 Dec 24;257(3):430–437. doi: 10.1016/j.jtbi.2008.12.011

Figure 1.

Figure 1

The motor-microtubule binding kinetics are adapted from Craciun et al (Craciun et al., 2005). The model contains five states, S, which are differentiated using the following subscript nomenclature: P represents a paused motor (i.e. V = 0), M represents a moving motor (i.e. V > 0), K represents the molecular motor kinesin, D represents the molecular motor dynein, and O represents an off-track motor. Using this nomenclature, we obtain the following states: SO) off-track, paused; SKP) kinesin, on-track, paused; SDP) dynein, on-track, paused; SKM) kinesin, on-track, moving anterogradely; SDM) dynein, on-track, moving retrogradely. Rate constants are shown in parameter-form as given in Craciun et al (Craciun et al., 2005). The tuned slow transport rate parameters are γ = 2.5 and λ = 0.1. Fast transport rate parameters are γ = 0.2 and λ = 10. For details regarding the derivation of rate constants and equations, see Craciun et al (Craciun et al., 2005).