Figure 4.

Slow transport of neurofilaments. To obtain an experimentally equivalent velocity profile for slow transport of neurofilaments, no cooperativity is required. That is, only one bound motor is needed per cargo. The figure shows the velocity histogram of a population of average-sized neurofilaments (L_NF =1.6 μm and D_NF = 10 nm). Note that for visual clarity the zero velocity bin (0 μm/s ) as been moved to the inset. Thus, the inset shows the number of cargos that remained paused during the length of the simulation (i.e. ~83% of cargos had velocities equal to 0 μm/s over the 4.74 second simulated period, similar to the 85% seen experimentally (Brown et al., 2005)).