Table 1.
Tissue ATP Content in Mature and Aged Male and Female Hearts at 15 Minutes of Reperfusion
ATP μM/g Dry Weight |
Probability |
||||||||
---|---|---|---|---|---|---|---|---|---|
Mature Male | Mature Female | Aged Male | Aged Female | Age | Gender | Age × Gender | Mature Male vs Female | Aged Male vs Female | |
Control | 23.0 (1.4) | 22.6 (1.2) | 22.4 (1.5) | 22.8 (1.5) | 0.8794 | 0.9977 | 0.7902 | 0.8390 | 0.8612 |
GI | 9.0 (1.2) | 9.6 (0.8) | 7.5 (1.0) | 6.8 (1.0) | 0.0397 | 0.9582 | 0.5652 | 0.7079 | 0.6650 |
K/Mg | 11.7 (0.9) | 11.4 (1.2) | 8.6 (0.7) | 7.8 (0.4) | 0.0004 | 0.4984 | 0.8387 | 0.7880 | 0.3645 |
K/Mg + DZX | 12.2 (1.0) | 13.5 (0.8) | 9.4 (0.7) | 7.6 (0.4) | <0.0001 | 0.7354 | 0.0497 | 0.3240 | 0.0452 |
Mature and aged, male and female tissue ATP concentration content (μM/g dry weight) for Control (after 75 minutes of perfusion) and in GI, K/Mg and K/Mg + DZX after 30 minutes of equilibrium, 30 minutes of ischemia. 15 minutes of reperfusion. All results are shown as mean (SEM) for n = 6 animals for each group. P values for specific comparisons between male and female animals, within an age group were calculated using a t test. Significant differences at p < 0.05 are shown in bold face.
ATP = adenosine triphosphate; DZX = diazoxide; GI = global ischemia; K/Mg = potassium/magnesium.