Table 2. Odds ratios and estimated coefficients from multivariable logistic regression models based on 10 fatty acids (FA) and standard risk factors (SRF) separately and combined from the derivation set (per 1 SD; n = 898).
| Variable | Structure | 1 SD (% of totalFAs) | FA and SRF Separately | FA and SRF Combined | ||||||
| Odds Ratio | 95% CI* | Est. (β) | SE | Odds Ratio | 95% CI* | Est. (β) | SE | |||
| FA | ||||||||||
| Intercept | - | - | - | - | 34.55 | 3.42 | - | - | 7.29 | 2.67 |
| Linoleic acid (n-6) | C18:2 | 2.79 | 0.15 | 0.10 to 0.21 | −1.88 | 0.19 | 0.17 | 0.10 to 0.24 | −1.78 | 0.21 |
| Stearic acid | C18:0 | 1.72 | 0.22 | 0.15 to 0.30 | −1.50 | 0.17 | 0.22 | 0.14 to 0.30 | −1.52 | 0.18 |
| Docosahexaenoic acid (n-3) | C22:6 | 1.50 | 0.33 | 0.23 to 0.41 | −1.12 | 0.13 | 0.37 | 0.26 to 0.48 | −0.99 | 0.14 |
| alpha Linoleic acid (n-3) | C18:3 | 0.23 | 0.35 | 0.24 to 0.48 | −1.04 | 0.16 | 0.32 | 0.21 to 0.44 | −1.13 | 0.16 |
| gamma Linolenic acid (n-6) | C18:3 | 0.10 | 0.42 | 0.29 to 0.56 | −0.87 | 0.13 | 0.46 | 0.31 to 0.62 | −0.78 | 0.14 |
| Palmitoleic acid | C16:1 | 0.69 | 0.43 | 0.27 to 0.63 | −0.85 | 0.21 | 0.43 | 0.25 to 0.67 | −0.85 | 0.24 |
| Arachidonic acid (n-6) | C20:4 | 3.12 | 0.43 | 0.30 to 0.58 | −0.84 | 0.17 | 0.44 | 0.29 to 0.60 | −0.83 | 0.18 |
| trans Palmitoleic acid | trans C16:1 | 1.04 | 0.76 | 0.63 to 0.91 | −0.27 | 0.10 | 0.76 | 0.62 to 0.92 | −0.27 | 0.10 |
| Eicosadienoic acid (n-6) | C20:2 | 0.06 | 1.37 | 1.12 to 1.73 | 0.31 | 0.11 | 1.43 | 1.15 to 1.85 | 0.36 | 0.11 |
| trans Oleic acid | trans C18:1 | 0.84 | 1.37 | 1.06 to 1.82 | 0.31 | 0.12 | 1.32 | 1.02 to 1.78 | 0.27 | 0.12 |
| SRF | ||||||||||
| Intercept | - | - | - | - | 10.97 | 2.05 | - | - | - | - |
| Male | - | - | 0.77 | 0.55 to 1.06 | 0.27 | 0.16 | 0.92 | 0.56 to 1.51 | −0.09 | 0.23 |
| Hypertension | - | - | 1.35 | 1.00 to 1.85 | 0.30 | 0.16 | 1.17 | 0.76 to 1.84 | 0.16 | 0.21 |
| Diabetes Mellitus | - | - | 1.10 | 0.74 to 1.59 | 0.09 | 0.19 | 0.79 | 0.46 to 1.31 | −0.24 | 0.26 |
| Current Smoker | - | - | 3.53 | 2.43 to 5.29 | 1.26 | 0.19 | 2.86 | 1.79 to 5.07 | 1.05 | 0.26 |
| Age (per 10 years) | - | - | 1.19 | 1.04 to 1.36 | 0.17 | 0.06 | 1.10 | 0.91 to 1.33 | 0.10 | 0.09 |
| Total-C† (per SD≈43 mg/dL) | - | - | 0.82 | 0.78 to 1.05 | −0.19 | 0.08 | 0.95 | 0.75 to 1.19 | −0.05 | 0.11 |
| HDL-C† (per SD≈16 mg/dL) | - | - | 0.54 | 0.40 to 0.59 | −0.62 | 0.09 | 0.56 | 0.43 to 0.71 | −0.57 | 0.12 |
*
95% confidence intervals obtained using bootstrapping method with 10,000 replicates.
†
Natural log transformation was modeled.