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. Author manuscript; available in PMC: 2009 Apr 27.
Published in final edited form as: Development. 2008 Aug 28;135(19):3291–3300. doi: 10.1242/dev.022871

Figure 6.

Figure 6

IRS1 is present in Shh-mediated mouse medulloblastoma. (A) Hematoxylin and eosin staining of a Neuro-D2-SmoA1 medulloblastoma depicts a desmoplastic medulloblastoma. (B) Adjacent normal cerebellar areas in the SmoA1 tumor model show very little IRS1 (red) immunostaining. (C-D) Increased IRS1 protein can be seen within the tumor at both 10X and 63X magnification (blue=DAPI). (E) Western blot analysis for both Patched +/- and SmoA1 medulloblastoma models show increased IRS1 expression coinciding with increased cyclin D2 expression.