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. 2007 May 8;3:111. doi: 10.1038/msb4100148

Figure 1.

Figure 1

Exploring the relative importance of IκB degradation mechanisms by computational parameter sensitivity analysis. (A) Schematic of the NF-κB signaling module and its physiological importance in the transduction of diverse inflammatory, developmental, and stress signals. (B) Illustration of the four IκB degradation pathways within the NF-κB signaling module. deg1 and deg4 are IKK-independent degradation rate constants for free and bound IκBα. r1 and r4 are IKK-dependent degradation rate constants for free and bound IκBα. (C) Computational simulation of NF-κB activation over a 6-h time course. TNF stimulation begins at time 0, and is removed at 4 h. Mean activity in the first hour of stimulation and the second hour after removal of the stimulus (shaded in gray) were used to create the plots in (D–F) and (G). (D–G) Graphs showing the average nuclear NF-κB (y axis) during the first hour (D, F) or during the second hour after 4 h (E, G) of TNF stimulation for different values (x axis) of the IKK-dependent (D, E) or -independent (F, G) degradation rate constants of free (blue line) and bound (red line) IκB.