Table 1.
Rate constants for IKK-independent IκB degradation: a role for NF-κB
| Rate constants (s−1) | NF-κB effect | ||
|---|---|---|---|
| IκBα | |||
| Free | deg1:2 × 10−3 | 2000 | |
| Bound | deg4:1 × 10−6 | ||
| IκBβ | |||
| Free | deg2:3 × 10−3 | 3000 | |
| Bound | deg5:1 × 10−6 | ||
| IκBɛ | |||
| Free | deg3:3 × 10−3 | 3000 | |
| Bound | deg6:1 × 10−6 | ||
New rate constants governing the uninduced IKK-independent degradation of IκB proteins derived from experiments in this paper and used in an updated version of the mathematical model. The ratio of IκB degradation rate constants in the presence and absence of NF-κB is defined as the ‘NF-κB effect'.