Table 1.
Results from drug targets search by MTOI
| Rank | Enzyme | abs(m.d./s.d.) | m.d. |
|---|---|---|---|
| 1 | PLA2 | 0.9081 | −1 |
| 2 | LTA4H | 0.8135 | −0.84 |
| 3 | 5-LOX | 0.774 | −0.88 |
| 4 | PGES | 0.7199 | −0.72 |
| 5 | COX-2 | 0.6748 | −0.72 |
| 6 | PHGPx | 0.538 | 0.6 |
| 7 | TXAS | 0.1756 | 0.2 |
| 8 | CYP4F3 | 0.1063 | 0.12 |
| 9 | PGDS | 0.1041 | 0.12 |
| 10 | 12-LOX | 0.1022 | 0.12 |
| 11 | 15-LOX | 0.0699 | 0.08 |
| 12 | CR | 0.0349 | 0.04 |
| 13 | 15-PGDH | 0 | 0 |
| 14 | COX-1 | 0 | 0 |
| 15 | 9-KPR | 0 | 0 |
| 16 | PGFS | 0 | 0 |
| 17 | PGIS | 0 | 0 |
The parameter set used is the same as in Figure 3. The top five enzymes were selected as drug targets and their corresponding regulations were all predicted to be inhibition.