Table 2.

Multi-target control solutions found by MTOI

No.	PLA2	COX-2	PGES	5-LOX	LTA4H	COX-1	Frequency	〈S〉
1	√	√	—	—	—	√	1	0.0011
2	√	√	√	—	—	√	1	0.0011
3	—	√	√	√	√	√	5	0.002
4	—	√	√	—	√	√	5	0.0021
5	—	—	√	√	√	—	2	0.0026
6	√	√	√	√	√	√	5	0.0028
7	—	√	√	√	—	√	5	0.0033
8	√	√	√	—	√	√	5	0.0034
9	—	√	—	√	√	√	5	0.0036
10	√	√	—	√	√	√	5	0.0037
11	√	√	√	√	—	√	5	0.0041
12	√	√	—	—	√	√	5	0.0042
13	—	√	—	—	√	√	5	0.0048
14	√	—	√	√	√	—	1	0.0057
15	—	—	√	√	—	—	2	0.0061
16	—	—	√	—	√	—	3	0.0072
17	√	√	—	√	—	√	5	0.0075
18	—	√	—	√	—	√	5	0.01
19	√	—	√	—	√	—	1	0.0123
20	√	—	√	√	—	—	1	0.0241
21	√	—	—	√	√	—	1	0.0431
22	√	—	—	—	√	—	1	0.0569
23	√	—	—	√	—	—	1	0.0624

The frequency of MTOI solutions appearing in five parameter sets was also shown. The sensitivity 〈S〉 is averaged over the parameter sets in which the solution appeared. ‘—' denotes no regulation and ‘√‘ denotes that the corresponding enzyme is inhibited.