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. Author manuscript; available in PMC: 2009 Apr 27.
Published in final edited form as: Neuron. 2006 Nov 22;52(4):663–677. doi: 10.1016/j.neuron.2006.09.029

Figure 4. Induction of synaptic homeostasis in real time.

Figure 4

A) mepsp, EPSP and quantal content are plotted over time for a single recording (normalized to baseline values prior to toxin application). Time zero is the time of toxin application. EPSPs delivered at 0.2Hz are averaged every 50 s. mepsps are averaged over identical 50 s intervals. Quantal content is calculated based on these average measurements for each 50 s interval. Baseline stimulation is followed by a perfusion with PhTox (4μM) that remains present in the bath solution throughout the remainder of the recording. 10 stimuli are delivered immediately following PhTox application to maximally suppress mepsp amplitudes (amplitudes not shown on graph). 0.2Hz stimulation is then resumed for the duration of the experiment in the continued presence of PhTox. B) EPSP amplitudes for the experiment in (A). C) Average values for experiments performed as in (A) without the addition of PhTox (n=10). D) Average values for all experiments that included PhTox as in (A) (n=12).