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Influence of low or high cytotoxic T lymphocyte precursor assay (CTLp) frequency on C-peptide production is shown for tacrolimus–mycophenolate mofetil (TAC–MMF) (a, n = 20), TAC–sirolimus (SIR) (b, n = 5) or SIR only (c, n = 5) patients. The combined analysis of all non-TAC–MMF patients a high donor alloantigen-specific CTLp frequency was associated with significantly lower C-peptide levels (P = 0·03, Mann–Whitney U-test).
