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. 2009 Apr;156(1):172–182. doi: 10.1111/j.1365-2249.2008.03872.x

Fig. 1.

Fig. 1

Effects of MG132 on interleukin-10-deficient (IL-10−/−) mice. (a) Histological findings in IL-10−/− mice. Sections of the cecum, proximal colon, transverse colon and rectum were collected at necropsy (on day 28) and stained with haematoxylin and eosin. Left panel, vehicle-treated IL-10−/− mice; right panel, MG132-treated (15·0 µmol/kg) IL-10−/− mice (original magnification 100×). (b) Histological score in IL-10−/− mice treated with the indicated doses of MG132. Histological damage was quantified by the scoring system described by Sellon et al. (n = 8 in each group). *P < 0·05 compared with vehicle-treated IL-10−/− mice. (c) Tumour necrosis factor-α gene expression in the colonic tissues of IL-10−/− mice treated with MG132. *P < 0·05 compared with vehicle-treated IL-10−/− mice (n = 8 in each group).