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. 2009 Apr 15;136(10):1761–1770. doi: 10.1242/dev.034157

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Fig. 5. — Atrial and atrioventricular septal defects in Gli1CreER^T2 conditional Smo mutants. (A-D) E14.5 cardiac anatomy by cross-section histology in control Smo^fl/fl (A,C) and mutant Smo^Gli1-CreERT2 (B,D) embryos administered with TM at E7.5 and E8.5. Atrial septal (D, arrowhead) and atrioventricular canal (D, asterisk) defects are present in Smo^Gli1-CreERT2 but not Smo^fl/fl embryos. C and D correspond to boxes in A and B, respectively. (E,F) Smo^Gli1-CreERT2 embryos (F) at E10.5 show hypoplastic dorsal mesenchymal protrusions (DMP, arrow) as compared with wild-type Smo^fl/fl littermates (E). AS, atrial septum.