Skip to main content
. Author manuscript; available in PMC: 2010 Apr 24.
Published in final edited form as: Brain Res. 2009 Mar 9;1267:1–8. doi: 10.1016/j.brainres.2009.02.059

Figure 5. Putative Lis1- and Dab1-containing protein complexes at different developmental ages.

Figure 5

At prenatal agesthe Pafah1b complex consists mostly of Alpha1 dimers and Lis1. Dab1 binds VLDLR, and is heavily phosphorylated by SFKs in response to Reelin. Dab1 also binds ApoER2 (not shown). PhosphoDab1 binds Lis1 in addition to other signaling molecules (not shown for simplicity). VLDLR, but not ApoER2, also binds Alpha1. At perinatal ages, as Alpha1 levels decrease and Alpha2 levels increase new complexes form. The Pafah1b complex becomes heterotrimeric, and Alpha2 competes and displaced Alpha1 from VLDLR. Levels of Dab1 phosphorylation drop and Alpha2 binds Dab1 instead of Lis1. At postnatal ages the Pafah1b complex contains mostly Alpha2 and Lis1. A multiprotein VLDLR-Alpha2-Dab1 complex may form.