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Long-term effects of calorie restriction (CR) and protein restriction (PR) on serum IGF-1 concentration. Serum IGF-1 concentration (A), IGF-1 : IGFBP-3 ratio (B), and the serum concentrations of insulin (C) and C-reactive protein (D) from the cross-sectional comparison of individuals who were habitually consuming a low protein diet, a low calorie diet, or a typical Western diet. Data are mean ± standard error. *p ≤ 0.01 vs. the low calorie group. †p ≤ 0.01 vs. the Western diet group.
