Table 1.
Association of plasma vitamin B12 levels with FUT2 genotypes in women participants from GWAS and replication studies
| SNP Association by Study | Age | N | Allele Freq | Estimate (S.E.)c | P-valued | |||
|---|---|---|---|---|---|---|---|---|
| Geometric Mean (95% CI), pg/ml |
||||||||
| rs602662 GWAS | G (Gly)=0.49 | Ser/Ser | Ser/Gly | Gly/Gly | ||||
| NHS CGEMS | 59 | 1,658 | 489.82 | 418.67 | 417.05 | −0.08 (0.01) | 6.54 × 10−10 | |
| (472.24–508.06) | (407.74–429.90) | (401.29–433.43) | ||||||
| Replication | ||||||||
| Combined NHS | 63 | 1,056 | 483.68 | 406.96 | 409.60 | −0.08 (0.02) | 1.13 × 10−06 | |
| Colorectal (CR e) | (461.78–506.63) | (393.69–420.67) | (390.22–429.93) | |||||
| Adenoma and CR Cancer | ||||||||
| Case-control Datasets | ||||||||
| TOTAL (GWAS and Replication) e | 487.72 | 413.35 | 413.52 | −0.08 (0.01) | 3.52 × 10−15 | |||
| (473.80–502.06) | (404.83–422.06) | (401.14–426.27) | ||||||
| rs601338b | aA (Trp)=0.51 | Nonsecretor | Secretor | Secretor | ||||
| (X/X) | (X/Trp) | (Trp/Trp) | ||||||
| GWAS | ||||||||
| NHS CGEMS | 59 | 1,658 | 496.60 | 418.69 | 418.32 | −0.08 (0.01) | 4.11 × 10−10 | |
| (477.89–516.04) | (407.76–429.92) | (403.36–433.84) | ||||||
| rs492602 GWAS | a A=0.51 | GG/GG | AG/AG | AA/AA | ||||
| NHS CGEMS | 59 | 1,637 | 496.02 | 419.95 | 416.97 | −0.08 (0.01) | 2.68 × 10−10 | |
| (477.32–515.45) | (408.88–431.31) | (402.14–432.35) | ||||||
| Replication | ||||||||
| Combined NHS CR | 63 | 1,059 | 491.13 | 407.67 | 406.61 | −0.10 (0.02) | 5.60 × 10−09 | |
| Adenoma and CR Cancer | (469.03–514.26) | (394.34–421.45) | (389.46–424.53) | |||||
| Case-control Datasets | ||||||||
| TOTAL (GWAS and Replication)f | 493.89 | 414.27 | 412.70 | −0.09 (0.01) | 5.36 × 10−17 | |||
| (479.42–508.81) | (405.69–423.04) | (401.33–424.40) | ||||||
a
Major allele according to HapMap CEU data
b
Imputed distribution for nonsense polymorphism, rs601338 (also known as W143X)
c
Estimates (regression coefficients) calculated from linear regression adjusted for age using log-transformed plasma vitamin B12 (same estimates obtained when adjusting for age, assay batch and total dietary methyl status)
d
P-values: GWAS and replication p-values are calculated from linear regression adjusted for age
e
colorectal is abbreviated as CR
f
Dominant model p-value for the joint analysis: rs602662 = 1.35 × 10−39; rs492602= 8.26 × 10−45