Figure 3.

Mechanism of action of cyclosporine, tacrolimus, and sirolimus. Adapted with permission from Wu FL, Tsai MK, et al. 2005. Effects of conversion from sirolimus oral solution to tablets in stable Taiwanese renal transplant recipients. J Formos Med Assoc, 104:22–8. © The Formosan Medical Association.

Abbreviations: CsA, cyclosporine; Ca, calcium; FK506, tacrolimus; KBP, FK binding protein; INF-γ, γ-interferon; IL, interleukin; mTOR; mammalian target of rapamycin; RAD; everolimus; SRL, sirolimus.