Table 1.

Key randomized studies with aprepitant

	Poli-Bigelli et al 2003		Hesketh et al 2003		Warr et al 2005
No. patients	569		530		866
Chemotherapy	Cisplatin		Cisplatin		Anthr + Cyclo
CR rates	NK1 vs control		NK1 vs control		NK1 vs control
Acute vomiting % (Day 1)	82.8	68.4	89.2	78.1	88	77
Delayed vomiting % (Days 2–5)	67.7	46.8	74.4	55.8	81	69
Overall control % (Days 1–5)	62.7	43.3	72.7	52.3	51	42

Abbreviations: Anthr, anthracycline; Cyclo, cyclophosphamide; NK1, neurokinin 1 receptor.