Figure 10. Consequences of GRP78 overexpression on insulin sensitivity in awake ob/+ and ob/ob mice.

(A–C) Hepatic glucose production (A), glucose utilization (B), and glucose infusion rate (GIR; C) were measured in ob/+ and ob/ob mice treated with Ad β-gal or Ad GRP78 during hyperinsulinemic-euglycemic clamps. *P < 0.05, **P < 0.01, ***P < 0.001 versus respective ob/+ value; ^#P < 0.05, ^##P < 0.01 versus respective Ad β-gal value.