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. 2009 Apr 13;119(5):1201–1215. doi: 10.1172/JCI37007

Figure 7. SREBP-2 and SREBP-2 target gene expression in the livers of ob/+ and ob/ob mice overexpressing GRP78.

Figure 7

Mice were injected with Ad β-gal or Ad GRP78, and livers were collected in the fed state 72 h later for the preparation of total RNA. Shown are relative levels of SREBP-2, hydroxymethylglutaryl-CoA reductase (HMG CoAR), LDL receptor (LDL-R), hydroxymethylglutaryl-CoA synthase (HMG CoAS), squalene synthase, and farnesyl 1,6 diphosphatase (Farnesyl 1,6 diP) mRNA measured by qRT-PCR. Results are mean ± SEM (n = 5–6 per group). ***P < 0.001 versus respective ob/+ value; #P < 0.05, ##P < 0.01, ###P < 0.001 versus respective Ad β-gal value.